Miriam promises her lovers the gift of eternal life, but John, her companion for centuries, suddenly discovers that he is getting old minute by minute, so he looks for Dr. Sarah Roberts, a researcher on the mechanisms of aging, and asks her for help.

Inspector Sylvester is assigned to investigate the violent murder of a fashion house model Isabella, by a masked assailant. As the investigation proceeds all of the house’s various sins, including corruption, abortions, blackmail and drug addiction, begin to come to light. It turns out that Isabella had kept a diary detailing these vices, and now almost every employee becomes nervous.

After carefree teenager Jay sleeps with her new boyfriend, Hugh, for the first time, she learns that she is the latest recipient of a fatal curse that is passed from victim to victim via sexual intercourse. Death, Jay learns, will creep inexorably toward her as either a friend or a stranger. Jay’s friends don’t believe her seemingly paranoid ravings, until they too begin to see the phantom assassins and band together to help her flee or defend herself.